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KMID : 1189420030160010100
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2003 Volume.16 No. 1 p.100 ~ p.111
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Inhibitory Effect on Melanogenesis of Rhizoma Bletillae
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Yoon Hwa-Jung
Yoon Jung-Won
Yoon So-Won
Ko Woo-Shin
Woo Won-Hong
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Abstract
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Recently many efforts were focused to understand the mechanical insights of melanogenesis to develop the agents for hyper-pigmentation and hypo-pigmentation. In the melanin biosynthetic pathway, tyrosinase is the rate limiting enzyme, and α-melanocyte stimulating hormone(MSH) or cAMP-elevating agents stimulate melanogenesis and enhance the melanin synthesis and the tyrosinase activity. The author has analyzed the effects of Rhizoma Bletillae on the basal melanogenic activities of B16 mouse melanoma cells. Rhizoma Bletillae alone markedly suppressed melanin content and tyrosinase activity in a dose-dependent manner. Pretreatment of the cells with Rhizoma Bletillae. The decrease in the tyrosinase activity was paralled by a decrease in the abundance of tyrosinase protein and tyrosinase promoter activity. These results suggest that Rhizoma Bletillae inhibits melanogenesis of B16 melanoma cells via suppression of tyrosinase activity.
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KEYWORD
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Rhizoma Bletillae , Melanogenesis , Tyrosinase activity , Melanin content
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